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Top-10 Cat Flea And Tick Preventions
Loved in the USA

Handpicked for quality & trusted by thousands of customers

Sponsored

NEXTSTAR F
NEXTSTAR

NEXTSTAR Flea and Tick Prevention for Cats, Repellent, and Control, Fast Acting Waterproof Topical Drops for Cats Over 3.5 lbs, 6 Month Dose

#1
Top Rated in the USA
PetArmor P
PetArmor

Born in the USA

PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 12 Doses, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

Fast Delivery
9.8
56 522 reviews

Solid Value from a Trusted Brand

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1 265 bought in past month

Sponsored

NEXTSTAR F
NEXTSTAR

NEXTSTAR Flea and Tick Prevention for Cats, Repellent, and Control, Fast Acting Waterproof Topical Drops for Cats Over 3.5 lbs, 6 Month Dose

#2
FRONTLINE
Frontline

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

11%OFF

Fast Delivery
9.6
48 025 reviews

Item still has Pre-Tariff price

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1 163 bought in past month
Last Purchases
Ha***er
Philadelphia, PA
4d ago
Jo***ph
Los Angeles, CA
1d ago
Be***in
Houston, TX
4h ago
#3
Advantage
Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention Cats Over 9 lbs. 2-Month Supply

Fast Delivery
9.3
75 614 reviews

Solid Value from a Trusted Brand

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1 061 bought in past month
Good materials and workmanship at a great rate.
AmeliaChicago, IL
#4
Advecta Pl
Advecta

Born in the USA

Advecta Plus Flea Prevention for Cats, Cat and Kitten Treatment & Control, Small and Large, Fast Acting Waterproof Topical Drops, 6 Month Supply

Fast Delivery
9.1
11 607 reviews

Solid Value from a Trusted Brand

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959 bought in past month
Curated products trusted bytrust us brands
#5
CAPSTAR (n
Capstar

Born in the USA

CAPSTAR (nitenpyram) Oral Flea Treatment for Cats, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Cats 2-25 lbs, 6 Doses

Fast Delivery
8.8
38 837 reviews

Solid Value from a Trusted Brand

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857 bought in past month
#6
Cheristin
Cheristin

Born in the USA

Cheristin Flea Treatment & Prevention for Cats Fast acting topical flea treatment for cats over 1.8 lbs 6 Count

Fast Delivery
8.5
21 467 reviews

Solid Value from a Trusted Brand

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755 bought in past month
#7
Advantage
Advantage

Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention Cats 5-9 lbs. 4-Month Supply

Fast Delivery
8.3
37 440 reviews

Solid Value from a Trusted Brand

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653 bought in past month
#8
Seresto Ca
Seresto

Born in the USA

Seresto Cat Vet-Recommended Flea & Tick Treatment & Prevention Collar for Cats 8 Months Protection

Fast Delivery
8.0
42 784 reviews

Solid Value from a Trusted Brand

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551 bought in past month
#9
Seresto La
Seresto

Born in the USA

Seresto Large Dog Vet-Recommended Flea & Tick Treatment & Prevention Collar for Dogs Over 18 lbs. 2-Pack

Fast Delivery
7.7
109 433 reviews

Solid Value from a Trusted Brand

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449 bought in past month
#10
PetArmor C
PetArmor

Born in the USA

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Cats, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Cats 2-25 lbs, 6 Doses

Fast Delivery
7.5
16 540 reviews

Solid Value from a Trusted Brand

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347 bought in past month

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Adams Plus
Adams

Born in the USA

Adams Plus Flea & Tick Shampoo with Precor for Cats, Kittens, Dogs & Puppies Over 12 Weeks Of Age Sensitive Skin Flea Treatment Kills Adult Fleas, Flea Eggs, Ticks, and Lice 12 Ounces

21%OFF

Fast Delivery
30 067
verified reviews

Item still has Pre-Tariff price

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245 bought in past month
NEXTSTAR F
NEXTSTAR

NEXTSTAR Flea and Tick Prevention for Cats, Repellent, and Control, Fast Acting Waterproof Topical Drops for Cats Over 3.5 lbs, 3 Month Dose

Fast Delivery
1 256
verified reviews

Solid Value from a Trusted Brand

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143 bought in past month
TevraPet F
TevraPet

Born in the USA

TevraPet FirstAct Plus Flea and Tick Prevention for Cats Over 1.5lbs, 6 Monthly Doses, Topical Drops

Fast Delivery
13 593
verified reviews

Solid Value from a Trusted Brand

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41 bought in past month
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TevraPet A
TevraPet

Born in the USA

TevraPet Actispot II Flea Treatment for Large Cats 9+ lbs 6 Doses Powerful Prevention and Control

Fast Delivery
17 686
verified reviews

Solid Value from a Trusted Brand

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Flea and T
Cudory

Born in the USA

Flea and Tick Prevention for Cats – 500 Crunchy & Creamy Chews, Cat Flea Chewables with Skin & Coat Support – Oral Supplement for All Breeds & Ages – Natural Chicken Flavor

Fast Delivery
97
verified reviews

Solid Value from a Trusted Brand

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Our Top Picks

#1

Winner

PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 12 Doses, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

Rating
9.8
Chosen by1,265
Type of Prevention
Duration of Effectiveness
Age and Weight Restrictions

Most important from
56522 reviews

Type of Prevention
Effectively kills adult fleas, flea eggs, larvae, ticks, and chewing lice, breaking the entire flea life cycle.
Duration of Effectiveness
Starts working within 24 hours and provides reliable protection for up to 30 days per application.
Age and Weight Restrictions
Not ideal for cats under 1.5 pounds or those who prefer natural or oral treatment options.
Side Effects and Safety
Unscented and allergen-free, making it suitable for cats with sensitive skin.
Ease of Application
Application is straightforward and hassle-free, simply part the fur and apply at the shoulder blades.

PetArmor Plus Flea and Tick Prevention for Cats is a topical treatment designed for cats weighing over 1.5 pounds and aged 8 weeks or older. It contains the active ingredients fipronil and (s)-methoprene, which work together to kill fleas, flea eggs, larvae, ticks, and chewing lice. One of its strong points is that it helps break the flea life cycle, which means it doesn't just kill adult fleas but also prevents new infestations by targeting eggs and larvae. The formula is waterproof and fast-acting, starting to work within 24 hours and providing protection for up to 30 days per application. The pack includes 12 doses, enough to cover a full year of monthly treatment. It’s easy to apply by parting the cat’s fur at the shoulder blades and squeezing on the drops. Because the product can leave a greasy residue for about two days, you might need to clean the area gently if it seems excessive.

PetArmor Plus is unscented and allergen-free, which is helpful for sensitive cats. While generally safe if used as directed, it’s important to keep treated cats away from other pets and children until the product dries. Some users have reported mild side effects like temporary irritation, but this is uncommon. This product suits cat owners looking for a reliable, veterinarian-quality flea and tick treatment that is straightforward to use and provides lasting protection. It may not be ideal if you prefer natural or oral treatments, or if your cat is under 1.5 pounds.

Rating
9.8
Chosen by1,265
Type of Prevention
Duration of Effectiveness
Age and Weight Restrictions

Most important from
56522 reviews

Type of Prevention
Effectively kills adult fleas, flea eggs, larvae, ticks, and chewing lice, breaking the entire flea life cycle.
Duration of Effectiveness
Starts working within 24 hours and provides reliable protection for up to 30 days per application.
Age and Weight Restrictions
Not ideal for cats under 1.5 pounds or those who prefer natural or oral treatment options.
Side Effects and Safety
Unscented and allergen-free, making it suitable for cats with sensitive skin.
Ease of Application
Application is straightforward and hassle-free, simply part the fur and apply at the shoulder blades.
#2

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

Rating
9.6
Type of Prevention
Duration of Effectiveness
Side Effects and Safety

Most important from
48025 reviews

Type of Prevention
Using Frontline Plus regularly not only prevents fleas but also helps avoid more serious conditions like tapeworms, roundworms, and heartworms.
Duration of Effectiveness
Frontline Plus is highly effective when applied correctly every 30 days, ensuring cats remain flea and parasite free.
Side Effects and Safety
The product works wonders for both indoor and outdoor cats, keeping them free from fleas and ticks without any side effects or irritation.
Ease of Application
Applying the product at the base of the neck instead of between the shoulder blades makes it easier and more comfortable for the cat.

FRONTLINE Plus Flea and Tick Treatment for Cats is designed for cats weighing over 1.5 lbs and older than eight weeks. It is a waterproof and fast-acting solution that kills fleas, flea eggs, flea larvae, chewing lice, and ticks, including those that can transmit Lyme disease. The active ingredients, fipronil and (S)-methoprene, work together to break the flea life cycle and provide protection for up to 30 days with a single application.

This makes it a long-lasting option for pet owners looking to control infestations and prevent new ones from starting. The treatment is applied topically, which might require some effort to ensure it reaches the skin and not just the fur, but it is generally considered easy to use with clear instructions provided. However, care must be taken to avoid applying it to cats under 1.5 lbs or younger than eight weeks due to potential safety concerns.

Some users have reported side effects like temporary skin irritation at the application site, so monitoring your pet after application is recommended. Despite these minor drawbacks, FRONTLINE Plus has been trusted by pet owners for over 20 years and boasts a solid reputation. It is an excellent choice for those seeking a reliable and effective flea and tick prevention method for their cats.

Rating
9.6
Type of Prevention
Duration of Effectiveness
Side Effects and Safety

Most important from
48025 reviews

Type of Prevention
Using Frontline Plus regularly not only prevents fleas but also helps avoid more serious conditions like tapeworms, roundworms, and heartworms.
Duration of Effectiveness
Frontline Plus is highly effective when applied correctly every 30 days, ensuring cats remain flea and parasite free.
Side Effects and Safety
The product works wonders for both indoor and outdoor cats, keeping them free from fleas and ticks without any side effects or irritation.
Ease of Application
Applying the product at the base of the neck instead of between the shoulder blades makes it easier and more comfortable for the cat.
#3

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply

Rating
9.3
Side Effects and Safety
Ease of Application

Most important from
75614 reviews

Side Effects and Safety
Excellent product, really works and doesn’t bother our cat at all.
Ease of Application
Fleas be gone! Easy to use and not as expensive as other products.

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention is specifically designed for large cats over 9 lbs and at least 8 weeks old. This product stands out as an easy-to-apply monthly topical treatment that eliminates the need for hard-to-swallow pills and does not require a prescription. It's effective against adult fleas, flea larvae, and flea eggs, providing comprehensive protection.

The treatment starts working within 12 hours of application and remains effective for 30 days, ensuring continuous flea control for a month. Additionally, it is fragrance-free and waterproof, making it suitable for cats' daily activities after 24 hours of application. The active ingredients, Imidacloprid and Pyriproxyfen, are known for their efficacy in flea control.

It is crucial to follow the application instructions carefully to avoid any adverse effects, such as getting the product in the cat's eyes or ingestion. While the product is generally safe, some cats might experience mild side effects like skin irritation. The ease of application is greatly appreciated by pet owners, as it simplifies the process of flea prevention. This product is highly recommended for large cats who need reliable and effective flea treatment without the hassle of pills.

Rating
9.3
Side Effects and Safety
Ease of Application

Most important from
75614 reviews

Side Effects and Safety
Excellent product, really works and doesn’t bother our cat at all.
Ease of Application
Fleas be gone! Easy to use and not as expensive as other products.

Buying Guide for the Best Cat Flea And Tick Preventions

Choosing the right flea and tick prevention for your cat is crucial for their health and comfort. Fleas and ticks can cause a range of issues from mild irritation to serious diseases. When selecting a product, consider your cat's lifestyle, health status, and any specific needs they may have. It's important to understand the different types of preventions available and how they work to make an informed decision that best suits your cat's needs.
Type of PreventionFlea and tick preventions come in various forms such as topical treatments, oral medications, collars, and shampoos. Topical treatments are applied directly to the cat's skin and are effective for a month. Oral medications are ingested and can provide protection for up to three months. Collars release active ingredients over time and can last for several months. Shampoos provide immediate relief but need to be used regularly. Choose the type based on your cat's tolerance and your convenience.
Active IngredientsThe active ingredients in flea and tick preventions are what kill or repel the pests. Common ingredients include fipronil, imidacloprid, and fluralaner. Each ingredient works differently and may target different stages of the flea or tick lifecycle. It's important to choose a product with ingredients that are safe for cats and effective against the specific pests in your area. Consult your vet to determine which active ingredients are best for your cat.
Duration of EffectivenessThe duration of effectiveness refers to how long the prevention will protect your cat from fleas and ticks. This can range from a few days with shampoos to several months with collars. Consider how often you are willing to reapply or administer the prevention. For busy pet owners, longer-lasting options like collars or oral medications might be more convenient.
Age and Weight RestrictionsMany flea and tick preventions have age and weight restrictions to ensure safety and effectiveness. Products are often formulated for specific age groups, such as kittens or adult cats, and weight ranges. Always check the product label to ensure it is appropriate for your cat's age and weight. Using a product not suited for your cat can lead to ineffective treatment or potential health risks.
Side Effects and SafetyAll flea and tick preventions have the potential for side effects, which can range from mild skin irritation to more serious reactions. It's important to read the product label and consult with your vet about any potential side effects, especially if your cat has a history of allergies or sensitivities. Choose a product with a good safety profile and monitor your cat for any adverse reactions after application.
Ease of ApplicationThe ease of application can vary significantly between different types of flea and tick preventions. Topical treatments and collars are generally easy to apply, while oral medications may require more effort if your cat is resistant to taking pills. Shampoos require regular bathing, which can be challenging if your cat dislikes water. Consider your cat's temperament and your ability to administer the treatment when choosing a product.

FAQ